, Mg 2 + , NF - 3 kB and de novo ceramide

Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-κB, and de novo ceramide.

The present study tested the hypotheses that 1) short-term dietary deficiency (MgD) of magnesium (21 days) would result in the upregulation of ceramide synthase (CS) in left ventricular (LV), right ventricular, atrial, and aortic smooth muscle, as well as induce a synthesis/release of select cytokines and chemokines into the LV and aortic smooth muscle and serum; 2) exposure of primary cultured...

Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramide.

The present study tested the hypotheses that 1) short-term dietary deficiency of magnesium (21 days) in rats would result in the upregulation of sphingomyelin synthase (SMS) and p53 in cardiac and vascular (aortic) smooth muscles, 2) low levels of Mg(2+) added to drinking water would either prevent or greatly reduce the upregulation of both SMS and p53, 3) exposure of primary cultured vascular ...

Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg , NF- B, and de novo ceramide

Burton M. Altura, Nilank C. Shah, Gatha Shah, Aimin Zhang, Wenyan Li, Tao Zheng, Jose Luis Perez-Albela, and Bella T. Altura Departments of Physiology and Pharmacology and Medicine, Center for Cardiovascular and Muscle Research, and School of Graduate Studies Program in Molecular and Cellular Science, State University of New York Downstate Medical Center, Brooklyn; Bio-Defense Systems, Incorpor...

Expression of the receptor of advanced glycation end-products (RAGE) and membranal location in peripheral blood mononuclear cells (PBMC) in obesity and insulin resistance

Objective(s): The present study aimed to evaluate the receptor of advanced glycation end-products (RAGE), NF-kB, NRF2 gene expression, and RAGE cell distribution in peripheral blood mononuclear cells (PBMC) in subjects with obesity and IR compared with healthy subjects.Materials and Methods: The mRNA expression levels of RAGE, NF-kB, NRF...

Synergistic Activation of NF-kB by Tumor Necrosis Factor Alpha and Gamma Interferon via Enhanced IkBa Degradation and De Novo IkBb Degradation